Ofertes d'ocupació a Germans Trias i Pujol Research Institute (IGTP)

• Nivell d'experiència---
• Tipus de contracteConsultor
• Publicada1 d’oct.

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Job Description

The Clinical Genomics group is a multidisciplinary team performing clinical genomic tests to determine the genetic cause of different hereditary diseases as members of the Genetic Department at Hospital Germans Trias & Pujol. The Genetic Department has several important responsibilities, including diagnosing and monitoring patients with hereditary diseases, providing genetic counseling to patients and their families, and conducting genetic tests.

The group is also focused on increasing the cost-effectiveness of genetic testing and enhancing their knowledge of the genetic bases of various diseases. To achieve this goal, they are actively developing new genomic techniques to analyze germline and somatic variants at both RNA and DNA levels. Additionally, the group is participating in developing new methodologies to determine the status of known pharmacogenomics biomarkers and to validate different Polygenic Risk Scores for multifactorial diseases.

Furthermore, the group is a member of the Spanish Reference Center (CSUR) for adult patients with Phakomatoses (Neurofibromatoses, Schwannomatosis, Tuberous Sclerosis, and Von-Hippel Lindau diseases), which is a part of the European Network of Reference Centers (ERN) GENTURIS. Currently we are also the coordinators of international Variant Curation Expert Panel (VCEP) for Neurofibromatoses and Schwannomatosis by ClinGen (NIH) to stablish the variant classification ACMG rules for the genes causing these diseases. The group is also working on developing personalized medicine for this group of patients and developing new clinical guidelines that also take into account patients' emotional and social needs. They are also discovering new prognostic biomarkers, understanding the role of genomic alterations in the development of disease-associated lesions, and implementing various gene therapy strategies to cure these diseases.

We are seeking an organized, motivated and team-oriented molecular geneticist with previous experience in human genetics and NGS data analysis, especially clinical WES applying ACMG guidelines, with the desire to work in a multidisciplinary team focused in clinical genetics and translational research and to get involved mainly in the clinical genetic testing, quality assurance and in the different projects of the group.

Main Responsibilities

• As molecular geneticist, you will be in charge of Panel- NGS and WES analysis, in addition to elaborate clinical reports and participate in the quality assurance of the laboratory (ISO9001 and ISO15198)
• You will actively participate in the different clinical committees and meetings with other collaborators or centers to discuss patients diagnose, follow-up and treatment and also prepare the documentation required for those meetings / committees.
• As member of Clinical Genomics research group, you will also participate in the research activities, most centered in developing or validating tools for clinical genomic testing and tis publications.
• You will work on a daily basis in a multidisciplinary team with clinical staff, bioinformaticians, biologists and molecular geneticists.
• You will interact with experts in medicine, genetics and bioinformatics to jointly evaluate the different tools, software, etc. used in the group, participating in regular group meetings to understand clinical and research needs and help the team to improve them.
  
  

Qualifications And Experience

The following requirements are mandatory:

• Degree in biology, biochemistry, genetics or similar, with high human genetics knowledge. Applicants with degrees in other life sciences will be considered providing they can demonstrate expertise in human genetics. PhD in (human) genetics will be an asset.
• Knowledge of Next Generation Sequencing and genomic data analysis
• Previous experience in working with high-throughput genomic data, analyzing them and interpreting the results.
• Familiar with human genetic variants interpretation, annotation, in silico programs and with expertise in applying ACMG guidelines for genetic variants interpretation.
• Analysis of WES for clinical purposes and knowledge on ISO15189 will be an asset.
• Fluent English.
• Good organizational skills and excellent attention to detail.
• Ability to perform as a team member and must have good interpersonal skills
  
  

This position is intended for specialized technicians in molecular genetics who can progressively become independent in performing clinical genomic testing and also participating in the research projects in line with the group priorities

What We Offer

• Full time
• Start Date: October 2026
• Gross annual remuneration inherent to the square objected to this call, will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.
• Flexible payment (childminding vouchers).
• 23 days holiday and 5 days for personal matters.
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.
  
  

FOR MORE INFORMATION

https://www.germanstrias.org/en/research/cancer/22/clinical-genomics-unit-ugc

How To Apply

Interested persons must attach to the application:

• Motivation letter explaining their interest in the position.
• Updated CV.
• Contact of 2-3 references.
  
  

Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:

• Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.
• Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.
  
  

Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.

DEADLINE FOR APPLICATIONS

The deadline for the submission of applications closes on October 13, 2026

About Us

The Germans Trias i Pujol Research Institute (IGTP) is a public research centre located in Badalona. Its main objective is to increase scientific knowledge in order to transform it into solutions to improve the health and medical care of patients and the community.

The Institute is associated with one of the major university hospitals in the Barcelona area, the Germans Trias i Pujol Hospital, and is part of the Can Ruti biomedical campus. IGTP is a CERCA centre and is also accredited as a centre of excellence by the Instituto de Salud Carlos III (ISCIII) and is in charge of coordinating the management and scientific strategy of the campus, working in close collaboration with the other centres.

The Germans Trias i Pujol Research Institute carries out research within 9 areas:

• Cancer
• Cardiovascular and Respiratory Diseases
• Community Health
• Diseases of the Liver and Digestive Tract
• Endocrine and Diseases of the Metabolism, Bones and Kidneys
• Immunology and Inflammation
• Infectious Diseases
• Neuroscience
• Science of Behaviour and Substance Abuse
  
  

Scientists working in these areas publish an average of over 900 papers a year, contribute to improved treatment and healthcare protocols, produce patents and set up spin-off companies in order to improve the lives of patients.

The following video is a bird's eye view of Campus Can Ruti a top-tier translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

The IGTP, in its commitment to equal opportunities, guarantees equal treatment between candidates and persons with a degree of disability equal to or greater than 33 per 100, as accredited by the Spanish Autonomous Regions or the State Administration, or who have been declared to have a total permanent disability in a different profession through a resolution of the National Institute of Social Security, while retaining functional capacity for the completion of the tasks of the post will be positively considered.

• Nivell d'experiència---
• Tipus de contracteConsultor
• Publicada25 de set.

. Machine Learning

Job Description

We are offering a fully funded PhD position in statistical genomics and precision medicine, based at the Institut de Recerca Germans Trias i Pujol (IGTP, Badalona), under the supervision of Dr. Sílvia Bonàs-Guarch (PI), with co-supervision by Dr. Anne L. Madsen, at the Steno Diabetes Center Aarhus (Aarhus University Hospital, Denmark).

The position is funded through the Spanish “Proyectos de Generación de Conocimiento” call (PEICTI 2024-2027), via an FPI predoctoral contract, and is part of a newly funded research project on the molecular mechanisms underlying beta-cell dysfunction in type 2 diabetes (T2D), aimed at improving patient stratification and treatment optimisation using large-scale human genomics and exposome data.

Project

The PhD candidate will develop mechanism-specific polygenic scores for pancreatic islet beta-cell dysfunction, leveraging pleiotropy and regulatory genomics and generative machine-learning approaches, and will integrate them with exposure-based scores to build a joint genetic-exposure liability model for T2D subtyping. The project moves beyond global genetic risk models towards biologically-grounded interpretable predictor models of T2D heterogeneity, with direct applications in patient stratification and precision medicine. The student will work with large-scale resources including UK Biobank, in-house national GCAT cohort, and Danish population cohorts.

Environment

The candidate will join the Medical Genomics and Precision Medicine for T2D research line, led by Dr. Sílvia Bonàs-Guarch, within the Genomes for Life-GCAT Lab, supervised by Dr. Rafa de Cid. This research line focuses on understanding the molecular and environmental determinants that influence the risk and progression of type 2 diabetes. Within the broader GCAT Lab, the student will have direct access to population genomics infrastructure, computational resources and genetics and exposome expertise. Co-supervision and close collaboration with Dr. Anne L. Madsen (Steno Diabetes Center Aarhus) will provide hands-on training in OGTT-based beta-cell phenotyping and clinical epidemiology. The project is further embedded in an international collaborative network including the Dias & Frazer Lab (Centre for Genomic Regulation), Prof. Torben Hansen (Novo Nordisk Foundation Centre for Basic Metabolic Research, CBMR, Denmark) or Assoc. Prof. Chirag Patel (Harvard Medical School), among others, offering opportunities for training, research stays and high-impact publication

Funding conditions

• 4-year fully funded PhD position (FPI programme), Spanish national funding.
• Support for research stays abroad and conference attendance.
  
  

Main Responsibilities

The successful candidate will contribute to a research project aimed at developing molecularly-informed predictive models for type 2 diabetes by integrating large-scale human genomics and exposome data. The main duties will include:

• Develop mechanism-specific polygenic scores for pancreatic beta-cell dysfunction using GWAS datasets, pleiotropy-informed genetic models, regulatory functional genomics and advanced machine-learning approaches.
• Develop and evaluate exposure-based scores and integrate them with polygenic scores to build joint genetic-exposure liability models for patient stratification and precision medicine.
• Analyse and integrate large-scale genomic, phenotypic and exposome datasets from population cohorts, including the UK Biobank, the GCAT cohort and Danish population cohorts.
• Investigate the molecular and genetic heterogeneity underlying beta-cell dysfunction and type 2 diabetes through advanced statistical, computational and integrative genomics approaches.
• Translate genetic discoveries into clinically interpretable risk prediction models with applications in disease prediction, patient stratification and treatment optimisation.
• Prepare scientific manuscripts, present results at national and international conferences.
• Participate in collaborative research activities and international research stays with project partners, including the Steno Diabetes Center Aarhus (Denmark).
  
  

Qualifications And Experience

• MSc degree (or equivalent) in Bioinformatics, Computational Biology, Statistics, Data Science, Genetics, Biomedical Sciences, Biotechnology, Computer Science, or a related discipline.
• Candidates must fulfil the eligibility requirements for admission to an official PhD programme at a Spanish university.
• Experience with R/Python.
• Interest in human genetics, omics, complex diseases and data-driven biology.
• Strong analytical and problem-solving skills, ability to work independently within distributed team.
  
  

What We Offer

• Four-year full-time predoctoral contract (FPI) associated with the research project funded under the Spanish “Proyectos de Generación de Conocimiento” programme (PEICTI 2024–2027).
• Full-time position (100% dedication), in accordance with the applicable regulations for FPI predoctoral contracts.
• Date of incorporation: Jan 2027, upon completion of the recruitment process.
• Gross remuneration according to the salary scales established for FPI predoctoral contracts under the Spanish "Proyectos de Generación de Conocimiento" programme.
• The gross annual remuneration for this position will be determined based on the candidate's experience and skills, distributed over 12 payments.
• Flexible payment (childminding vouchers).
• 23 days holiday and 5 days for personal matters.
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.
  
  

FOR MORE INFORMATION

For more information contact Sílvia Bonàs Guarch (PI) at [email protected]

or see https://www.germanstrias.org/ca/projectes-estrategics/gcat/1/gcat-genomes-for-life#tab-2

How To Apply

Interested persons must attach to the application:

• Motivation letter explaining their interest in the position.
• Updated CV.
• Contact of 2-3 references.
  
  

Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:

• Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.
• Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.
  
  

Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.

DEADLINE FOR APPLICATIONS

The call for applications will close on 31st October 2026.

About Us

The Germans Trias i Pujol Research Institute (IGTP) is a public research centre located in Badalona. Its main objective is to increase scientific knowledge in order to transform it into solutions to improve the health and medical care of patients and the community.

The Institute is associated with one of the major university hospitals in the Barcelona area, the Germans Trias i Pujol Hospital, and is part of the Can Ruti biomedical campus. IGTP is a CERCA centre and is also accredited as a centre of excellence by the Instituto de Salud Carlos III (ISCIII) and is in charge of coordinating the management and scientific strategy of the campus, working in close collaboration with the other centres.

The Germans Trias i Pujol Research Institute carries out research within 9 areas:

• Cancer
• Cardiovascular and Respiratory Diseases
• Community Health
• Diseases of the Liver and Digestive Tract
• Endocrine and Diseases of the Metabolism, Bones and Kidneys
• Immunology and Inflammation
• Infectious Diseases
• Neuroscience
• Science of Behaviour and Substance Abuse
  
  

Scientists working in these areas publish an average of over 900 papers a year, contribute to improved treatment and healthcare protocols, produce patents and set up spin-off companies in order to improve the lives of patients.

The following video is a bird's eye view of Campus Can Ruti a top-tier translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

The IGTP, in its commitment to equal opportunities, guarantees equal treatment between candidates and persons with a degree of disability equal to or greater than 33 per 100, as accredited by the Spanish Autonomous Regions or the State Administration, or who have been declared to have a total permanent disability in a different profession through a resolution of the National Institute of Social Security, while retaining functional capacity for the completion of the tasks of the post will be positively considered.