PhD Fellowship on protein-DNA footprinting based on Atomic Force Microscopy (Marie Sklodowska-Curie SPM4.0 Doctoral Network) Join to apply for the PhD Fellowship on protein-DNA footprinting based on Atomic Force Microscopy (Marie Sklodowska-Curie SPM4.0 Doctoral Network) role at IBEC's Core Facilities Introduction to the Position We offer a 3-year PhD position within the Horizon Europe MSCA-Doctoral Network "Autonomous Scanning Probe Microscopy for Life Sciences and Medicine powered by Artificial Intelligence (SPM4.0)." Funded by the European Union (GA: 101168976), this project involves 16 PhD positions across 10 research centers, academic institutions, and 3 companies in Spain, Sweden, France, Germany, Italy, Poland, Czech Republic, and the UK.

Project Overview The SPM4.0 project aims to advance autonomous scanning probe microscopy integrated with artificial intelligence for applications in life sciences and medicine.

The initiative focuses on developing label-free, nanoscale imaging techniques of living cells and biomolecules, fostering Europe's leadership in this field.

Research Group and Activities The BIAT group at IBEC focuses on biomedical challenges of infectious diseases and bacterial transcription mechanisms.

The Nanobioelec group develops multiscale bioelectricity approaches using microscopy, electronics, and AI for medical applications.

Research Project Responsibilities * Grow and overexpress proteins in E. coli using microbiology techniques.

• Purify and characterize transcription factors.
• Perform biological assays such as EMSA and in vitro transcription assays related to bacterial virulence.
• Develop sample preparation protocols for DNA-protein footprinting compatible with scanning force microscopy and create training datasets.
• Validate neural network algorithms for DNA-protein footprinting.
• Apply methodologies to non-footprinted DNA-protein systems.
  
  

Candidate Requirements Essential: * BSc/MSc in Bioengineering, Life Sciences, Physics, Mathematics, or Engineering.

• Self-critical, quick learner, good communicator, team player, proactive, committed, with integrity and analytical skills.
• Proficient in English.
  
  

Advantageous: * Experience in molecular biology, microbiology, microscopy, or machine learning.

Eligibility Conditions * No doctoral degree at the start date.

• Enrolled in a PhD program in Spain.
• Mobility rule: no residence or main activity in Spain for more than 12 months in the past 36 months.
  
  

Offer Details * One position available.

• 3-year full-time contract, starting between March and April 2025.
• Approximate gross annual salary: €33,583.34, including family allowances based on MSCA-DN guidelines.
• Work-life balance measures, secondments, conference participation, and training opportunities.
  
  

Application Process Apply online via IBEC's careers site by 17/02/2025.

Include reference: PhD-GG.

For inquiries, contact ******.

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